Migrating To Europe Changes Gut Bacteria And Raises Heart Disease Risk

A joint study between the Kwame Nkrumah University of Science and Technology (KNUST) and Amsterdam UMC, a leading medical centre in the Netherlands, has found that migrants, in this case from West Africa to Europe, experience a ‘clear change’ in their microbiome composition as compared to their non-migrant peers in West Africa, which exposes them to an increase of cardiovascular disease.

The findings, published on April 6 in the journal Gut Microbes, show that participants who lost certain groups of gut microbes or acquired new ones had higher rates of cardiovascular risk factors such as hypertension, diabetes, obesity, and impaired kidney function.

“The results clearly demonstrate the importance of our findings in the relation to migration-related health outcomes,” explains postdoctoral researcher at Amsterdam UMC and first author of the study, Barbara Verhaar, who carried out the research together with colleagues at the University of Ghana and Kwame Nkrumah University of Science & Technology (KNUST).

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Respondents completed identical dietary questionnaires and provided both faecal and blood samples to determine the composition of their gut microbiomes.

Analyses revealed the presence of different microbes across the three groups, in line with the hypothesis that migration would affect microbiome composition.

The findings show that some groups of microbes disappear, and new ones emerge along the migration axis.

Health Outcomes

Previous studies, as well as the World Health Organisation, note that migrants frequently experience poorer health outcomes than native residents, and research from Amsterdam UMC has found this also to be the case in the Netherlands.

“This research underscores the relevance of gut health and how we look at the adverse health outcomes that are often associated with migration. It is fascinating to learn that when we migrate, we lose some relevant microbes we acquired in our home countries and pick up new microbes in the new countries, and this can influence our health very importantly. We found that macronutrient groups such as protein, fat and salt in food were strongest associated with gut microbiota composition, and these were higher in migrants, which might have contributed to the shift in gut microbiota composition. Future longitudinal studies are needed to verify these findings,” adds Charles Agyemang, Professor of Global Migration, Ethnicity & Health at Amsterdam UMC and senior author of the study.

Cardiometabolic risk is a growing concern for researchers across the globe, and Agyemang is currently leading a host of projects, both in the Netherlands and several African countries, that aim to develop better interventions to lower the risk of developing cardiometabolic diseases, such as diabetes and hypertension; and to improve management of cardiometabolic diseases.

As part of these efforts, as in this study, he works with the several institutions across the globe, especially in the African region to ensure that research in Amsterdam is strengthened with international data and, also, that research findings are translated into concrete policy.

“The findings of this study provide important insights into how migration can reshape our gut microbiota and subsequent health outcomes and emphasise the needs for north-south collaborations,” adds Ellis Owusu-Dabo, Professor of Epidemiology and Global Health and study lead from KNUST.

Other KNUST researchers involved in this study include Dr. Samuel Nkansah Darko from the Department of Molecular Medicine and Dr. Sampson Twumasi-Ankrah from the Department of Mathematics and Actuarial Science.

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